Association of pericardial adipose tissue with left ventricular structure and function: a region‐specific effect?

Abstract Background The independent role of pericardial adipose tissue (PAT) as an ectopic fat associated with cardiovascular disease (CVD) remains controversial. This study aimed to determine whether PAT is left ventricular (LV) structure and function other markers general obesity. Methods We studied 2471 participants (50.9 % women) without known CVD from the Korean Genome Epidemiology Study, who underwent 2D-echocardiography Doppler imaging (TDI) computed tomography measurement for PAT. Results Study more were likely be men had higher cardiometabolic indices, including blood pressure, glucose, cholesterol levels (all P < 0.001). Greater across quartiles increased LV mass index atrial volume 0.001) decreased systolic ( = 0.015) early diastolic TDI velocities, except ejection fraction. These associations remained after a multivariable-adjusted model traditional CV risk factors persisted even additional adjustment adiposity measures, such waist circumference body index. was also only obesity independently velocity Conclusions subclinical structural functional deterioration, these stronger than abdominal measures.